{"id":142,"date":"2026-06-21T23:17:00","date_gmt":"2026-06-21T14:17:00","guid":{"rendered":"https:\/\/shibata-kokyuki.com\/blog\/?p=142"},"modified":"2026-06-21T23:17:00","modified_gmt":"2026-06-21T14:17:00","slug":"post-142","status":"publish","type":"post","link":"https:\/\/shibata-kokyuki.com\/blog\/post-142\/","title":{"rendered":"COPD(\u6162\u6027\u9589\u585e\u6027\u80ba\u75be\u60a3)\u3068\u597d\u5869\u57fa\u7403"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306f\u9662\u9577\u304c\u5927\u5b66\u52e4\u52d9\u6642\u4ee3\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u305f\u7814\u7a76\u306b\u3064\u3044\u3066\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">COPD(\u6162\u6027\u9589\u585e\u6027\u80ba\u75be\u60a3)\u306f\u3001\u4e16\u754c\u4e2d\u3067\u7d042\u5104\u4eba\u304c\u7f79\u60a3\u3057\u3066\u3044\u308b\u6162\u6027\u306e\u80ba\u306e\u75c5\u6c17\u3067\u3059\u3002\u305f\u3070\u3053\u7159\u306a\u3069\u3092\u9577\u671f\u9593\u5438\u3044\u8fbc\u3080\u3053\u3068\u3067\u767a\u75c7\u3057\u3001\u7981\u7159\u3057\u305f\u5f8c\u3082\u9032\u884c\u3057\u3066\u3001\u54b3\u3001\u75f0\u3001\u547c\u5438\u56f0\u96e3\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u540c\u3058\u304f\u6c17\u9053\u304c\u72ed\u304f\u306a\u308b\u75c5\u6c17\u3067\u3042\u308b\u6c17\u7ba1\u652f\u5598\u606f\u306b\u3064\u3044\u3066\u306f\u3001\u8fd1\u5e74\u7814\u7a76\u304c\u9032\u307f\u3001IgE\u3084\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u6a19\u7684\u3068\u3057\u305f\u65b0\u3057\u3044\u85ac(\u6297\u4f53\u533b\u85ac)\u304c\u6b21\u3005\u3068\u767b\u5834\u3057\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3067COPD\u3001\u7279\u306b\u80ba\u6c17\u816b\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u8d77\u3053\u308b\u306e\u304b\u306b\u3064\u3044\u3066\u306f\u3001\u9577\u3089\u304f\u5206\u304b\u3063\u3066\u3044\u306a\u3044\u3053\u3068\u304c\u591a\u304f\u3001\u6839\u672c\u7684\u306a\u6cbb\u7642\u6cd5\u304c\u78ba\u7acb\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">COPD\u306e\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3092\u4f7f\u3063\u3066\u3001\u80ba\u6c17\u816b\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u4f5c\u3089\u308c\u308b\u306e\u304b\u3092\u8abf\u3079\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u4e3b\u5f79\u306f\u300c\u597d\u5869\u57fa\u7403\u300d\u3068\u3044\u3046\u5c11\u6570\u6d3e\u306e\u767d\u8840\u7403\u3060\u3063\u305f<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u6ce8\u76ee\u3057\u305f\u306e\u306f\u300c\u597d\u5869\u57fa\u7403\u300d\u3068\u3044\u3046\u8840\u6db2\u7d30\u80de\u3067\u3059\u3002\u767d\u8840\u7403\u306e\u4e2d\u3067\u30821%\u306b\u6e80\u305f\u306a\u3044\u3054\u304f\u5c11\u6570\u6d3e\u306e\u7d30\u80de\u3067\u3001\u3053\u308c\u307e\u3067\u3042\u307e\u308a\u7814\u7a76\u304c\u9032\u3093\u3067\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"391\" height=\"394\" src=\"https:\/\/shibata-kokyuki.com\/blog\/wp-content\/uploads\/2026\/06\/image.png\" alt=\"\" class=\"wp-image-143\" srcset=\"https:\/\/shibata-kokyuki.com\/blog\/wp-content\/uploads\/2026\/06\/image.png 391w, https:\/\/shibata-kokyuki.com\/blog\/wp-content\/uploads\/2026\/06\/image-298x300.png 298w\" sizes=\"auto, (max-width: 391px) 100vw, 391px\" \/><figcaption class=\"wp-element-caption\">\u9662\u9577\u306e\u597d\u5869\u57fa\u7403\u3067\u3059<\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u30de\u30a6\u30b9\u306e\u9f3b\u306b\u30a8\u30e9\u30b9\u30bf\u30fc\u30bc\u3068\u3044\u3046\u9175\u7d20\u3092\u5165\u308c\u308b\u3068\u3001\u30d2\u30c8\u306eCOPD\u306b\u3088\u304f\u4f3c\u305f\u80ba\u6c17\u816b\u3092\u8d77\u3053\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3053\u306e\u3068\u304d\u3001\u307e\u305a\u69d8\u3005\u306a\u767d\u8840\u7403\u304c\u80ba\u306b\u96c6\u307e\u3063\u3066\u304d\u3066\u708e\u75c7\u3092\u8d77\u3053\u3059\u306e\u3067\u3059\u304c\u3001\u9a5a\u3044\u305f\u3053\u3068\u306b\u3001\u597d\u5869\u57fa\u7403\u3060\u3051\u3092\u53d6\u308a\u9664\u3044\u305f\u30de\u30a6\u30b9\u3067\u306f\u80ba\u6c17\u816b\u304c\u8d77\u3053\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u3053\u306e\u7814\u7a76\u306b\u3088\u3063\u3066\u3001\u3053\u308c\u307e\u3067\u8b0e\u304c\u591a\u304b\u3063\u305fCOPD\u521d\u671f\u306e\u80ba\u6c17\u816b\u5f62\u6210\u30d7\u30ed\u30bb\u30b9\u304c\u3001\u7d30\u80de\u30fb\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u4eca\u5f8c\u3001\u30d2\u30c8\u306eCOPD\u3067\u3082\u540c\u69d8\u306e\u30d7\u30ed\u30bb\u30b9\u304c\u78ba\u8a8d\u3055\u308c\u308c\u3070\u3001\u597d\u5869\u57fa\u7403\u3084IL-4\u3001MMP-12\u3092\u6a19\u7684\u3068\u3057\u305f\u3001\u65b0\u3057\u3044\u4e88\u9632\u6cd5\u3001\u6cbb\u7642\u85ac\u306e\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u300c\u30c7\u30e5\u30d4\u30af\u30bb\u30f3\u30c8\u300d\u306e\u767b\u5834<\/h3>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u3082\u3061\u308d\u3093\u3001\u30c7\u30e5\u30d4\u30af\u30bb\u30f3\u30c8\u306f\u8ab0\u306b\u3067\u3082\u4f7f\u3048\u308b\u85ac\u3067\u306f\u306a\u304f\u3001\u65e2\u5b58\u306e\u5438\u5165\u85ac\u6cbb\u7642\u3067\u52b9\u679c\u304c\u4e0d\u5341\u5206\u306a\u60a3\u8005\u3055\u3093\u304c\u5bfe\u8c61\u3067\u3059\u3002\u9069\u5fdc\u306b\u3064\u3044\u3066\u306f\u4e3b\u6cbb\u533b\u3068\u3088\u304f\u3054\u76f8\u8ac7\u3044\u305f\u3060\u304f\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u300c\u9577\u5e74\u6cbb\u7642\u6cd5\u306e\u9032\u6b69\u304c\u4e4f\u3057\u304b\u3063\u305fCOPD\u300d\u306b\u65b0\u3057\u3044\u9078\u629e\u80a2\u304c\u5897\u3048\u305f\u3053\u3068\u306f\u3001\u60a3\u8005\u3055\u3093\u306b\u3068\u3063\u3066\u5fc3\u5f37\u3044\u30cb\u30e5\u30fc\u30b9\u3060\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f53\u9662\u3067\u3082\u300c\u80ba\u6c17\u816b\u300d\u300cCOPD\u300d\u306e\u60a3\u8005\u3055\u3093\u3092\u591a\u304f\u8a3a\u7642\u3057\u3066\u3044\u307e\u3059\u3002\u57fa\u790e\u7814\u7a76\u3067\u5f97\u305f\u77e5\u898b\u3092\u3001\u65e5\u3005\u306e\u8a3a\u7642\u306b\u3082\u6d3b\u304b\u3057\u3066\u3044\u304d\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Shibata S, et al. Basophils trigger emphysema development in a murine model of COPD through IL-4-mediated generation of MMP-12-producing macrophages. <em>Proc Natl Acad Sci U S A<\/em>. 2018.<\/li>\n\n\n\n<li>\u30b5\u30ce\u30d5\u30a3\u682a\u5f0f\u4f1a\u793e \u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u300c\u30c7\u30e5\u30d4\u30af\u30bb\u30f3\u30c8\u00ae\u3001COPD\u3092\u9069\u5fdc\u3068\u3059\u308b\u88fd\u9020\u8ca9\u58f2\u627f\u8a8d\u4e8b\u9805\u4e00\u90e8\u5909\u66f4\u627f\u8a8d\u3092\u53d6\u5f97\u300d2025\u5e743\u670827\u65e5<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4eca\u56de\u306f\u9662\u9577\u304c\u5927\u5b66\u52e4\u52d9\u6642\u4ee3\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u305f\u7814\u7a76\u306b\u3064\u3044\u3066\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002 COPD(\u6162\u6027\u9589\u585e\u6027\u80ba\u75be\u60a3)\u306f\u3001\u4e16\u754c\u4e2d\u3067\u7d042\u5104\u4eba\u304c\u7f79\u60a3\u3057\u3066\u3044\u308b\u6162\u6027\u306e\u80ba\u306e\u75c5\u6c17\u3067\u3059\u3002\u305f\u3070\u3053\u7159\u306a&#8230;<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"class_list":["post-142","post","type-post","status-publish","format-standard","hentry","category-incho"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - 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